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About the Author Mary C. Reiley， MS， is the Program Manager for the National Ambient Water Quality Criteria Program in the U.S. Environmental Protection Agency (USEPA). Reiley guides two teams that develop national ambient water-quality criteria for aquatic life and human health， provide technical assistance for criteria derivation and implementation to states， tribes， and other stakeholders， and conduct investigations into the fate， transport， bioavailability， and effects of toxics to aquatic life and human health. William A. Stubblefield， PhD， is a senior environmental toxicologist with Parametrix， Inc. Toxicology group in Corvallis， Oregon， USA. He also serves on the faculty of Oregon State University’s Department of Molecular and Environmental Toxicology. Dr. Stubblefield has 20-plus years experience in environmental toxicology， environmental assessment， and aquatic and wildlife toxicology studies. William J. Adams， PhD， is currently Principal Environmental Scientist for Rio Tinto， Salt Lake City， Utah， USA. He was previously Director of Environmental Science at Kennecott Utah Copper， Vice President of ABC Laboratories， and Science Fellow at Monsanto Company. Recent research interests include developing ecotoxicology risk assessment methods for metals， site-specific methodologies for water-quality criteria for metals， and development of a persistent， bioaccumulative， and toxic (PBT) approach for hazard assessment of metals. Dominic M. Di Toro， PhD， is presently Distinguished Professor of Civil and Environmental Engineering at the University of Delaware. Previously， he was the Donald J. O’Connor Professor of Environmental Engineering at Manhattan College. He is also a Principal Consultant at HydroQual， Inc. and has specialized in the development and application of mathematical and statistical analyses to stream， lake， estuarine， and coastal water-quality and sediment problems. Peter V. Hodson， PhD， is the Director of the School of Environmental Studies and a Professor of Biology at Queen’s University， Canada. Dr. Hodson has authored more than 100 technical publications in fish toxicology. His research has contributed to programs of water-quality management， most notably water-quality objectives for the Great Lakes， pulp mill effluent regulations， environmental effects monitoring programs， and policies on chlorine. Russell J. Erickson， PhD， is a research chemist at the Mid-Continent Ecology Division of the National Health and Environmental Effects Research Laboratory of the USEPA. His research has addressed the influence of exposure conditions on toxicity of chemicals to aquatic organisms， including effects of physicochemical variables on metal and ammonia toxicity; regulation of uptake of organic chemicals at fish gills; relationships among toxicity， chemical accumulation， and exposure time-series; metals toxicity via dietary exposure; and risks from photoactivated toxicity. F. James Keating Jr.， MS， is an Environmental Scientist with the USEPA in Washington DC. He currently works on the development and implementation of policy， regulations， and guidance for the review and approval of state and tribal water quality standards under the Clean Water Act. He has previously directed national assessments of contaminated sediment and mercury in fish tissue. His areas of expertise include human health and aquatic life risk assessment and the application of water-quality criteria for the protection of their uses.