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内容説明 A compendium of proven experimental approaches and strategies for studying the bioactivation， detoxification， tissue distribution， and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems， including the cytochrome P450 family， flavin-containing monooxygenases， glutathione， S-transferase， glucuronidation， N-acetylation， and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes， how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism， and how modulation of drug metabolism pathways can influence antiviral therapy.