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内容説明 The amide linkage is one of the most fundamental and widespread chemical bonds in nature， underlying the properties of a vast array of organic molecules， polymers， and materials， including peptides and proteins. Arthur Greenberg， Curt Breneman， and Joel Liebman’s peerless text provides comprehensive coverage of the experimental， structural， and computational findings that shed light on the chemical and physical properties of the amide linkage， as well as its emerging applications in materials and biotechnology.
Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors， cyclic peptides， antibacterial agents， and emerging nanotechnology applications. This one-of-a-kind study also: Discusses selected aspects of chemical reactions， structure， bonding， and energetics of the amide bond， including amide rotational barriers， stereochemistry， complexation， spectroscopy， and thermochemistry