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内容説明 ExpDesign Studio facilitates more efficient clinical trial designThis book introduces pharmaceutical statisticians， scientists， researchers， and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional Version 5.0 of ExpDesign Studio software that frees pharmaceutical professionals to focus on drug development and related challenges while the software handles the essential calculations and computations. After a hands-on introduction to the software and an overview of clinical trial designs encompassing numerous variations， Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio:Covers both classical and adaptive clinical trial designs， monitoring， and analysesExplains various classical and adaptive designs including groupsequential， sample-size reestimation， dropping-loser， biomarker-adaptive， and response-adaptive randomization designsIncludes instructions for over 100 design methods that have been implemented in ExpDesign Studio and step-by-step demos as well as real-world examplesEmphasizes applications， yet covers key mathematical formulationsIntroduces readers to additional toolkits in ExpDesign Studio that help in designing， monitoring， and analyzing trials， such as the adaptive monitor， graphical calculator， the probability calculator， the confidence interval calculator， and morePresents comprehensive technique notes for sample-size calculation methods， grouped by the number of arms， the trial endpoint， and the analysis basisWritten with practitioners in mind， this is an ideal self-study guide for not only statisticians， but also scientists， researchers， and professionals in the pharmaceutical industry， contract research organizations (CROs)， and regulatory bodies. It’s also a go-to reference for biostatisticians， pharmacokinetic specialists， and principal investigators involved in clinical trials.ERRATUM
Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio
By Mark ChangThe license for the ExpDesign Studio software on the CD included with this book is good for one-year after installation of the software. Prior to the expiration of this period， the software will generate a reminder about renewal for the license. The user should contact CTriSoft International (the owners of ExpDesign Studio) at www.CTriSoft.net or by email at license@ctrisoft.net， about renewal for the license.This should have been made clear in the first printing of this book. We apologize for this error.